Publications

Hilbert DW, Paulish-Miller TE, Tan CK, Carey AJ, Ulett GC, Mordechai E, Adelson ME, Gygax SE, Trama JP. 2012. Clinical Escherichia coli isolates utilize alpha-hemolysin to inhibit in vitro epithelial cytokine production. Microbes Infect [Epub ahead of print Jan 25].

Gallo-Ebert C, McCourt PC, Donigan M, Villasmil ML, Chen W, Pandya D, Franco J, Romano D, Chadwick SG, Gygax SE, Nickels JT Jr. 2012. Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi. Fungal Genet Biol 49(2): 101-113.

Hilbert DW. 2011. Uropathogenic E. coli: the pre-eminent urinary tract infection pathogen. In MM Rogers and ND Peterson (Ed.) E. coli Infections: Causes, Treatment and Prevention (pp. 1-67). Nova Science Publishers, Hauppauge, NY. In press.

Hilbert DW, Paulish TE, Mordechai E, Adelson ME, Gygax SE, Trama JP. 2009. Antimicrobial non-susceptibility of cervico-vaginal and rectal Escherichia coli isolates is associated with phylogeny and plasmid carriage. Eur J Clin Microbiol Infect Dis 28(11):1399-1403.

Gygax SE, Vermitsky JP, Self MJ, Chadwick SG, Mordechai E, Adelson ME, Trama JP. 2008. Antifungal Resistance of Candida glabrata Vaginal Isolates and the Development of a qRT-PCR-based Azole Susceptibility Assay. Antimicrob Agents Chemother 52(9):3424-3426.

Vermitsky JP, Self MJ, Chadwick SG, Trama JP, Mordechai E, Adelson ME, Gygax SE. 2008. A Survey of Vaginal-flora Candida species Isolates from Women of Different Age Groups by Use of Species-Specific PCR Detection. J Clin Microbiol 46(4):1501-1503.

Hilbert DW, Paulish TE, Mordechai E, Adelson ME, Trama JP. 2008. O serogroup, phylogeny and virulence factors of cervicovaginal and rectal Escherichia coli isolates. Eur J Clin Microbiol Infect Dis 27:1265-8.

Hilbert DW, Pascal KE, Libby EK, Mordechai E, Adelson ME, Trama JP. 2008. Uropathogenic Escherichia coli dominantly suppress the innate immune response of bladder epithelial cells by a lipopolysaccharide- and Toll-like receptor 4-independent pathway. Microbes Infect 10:114-21.

Gygax SE, Schuyler JA, Trama JP, Mordechai E, Adelson ME. 2007. Detection of Erythromycin and Clindamycin Resistance Genes in Group B Streptococcal Clinical Isolates and Cervicovaginal-Rectal Swabs. Microb Drug Resist 13(2):119-123.

Gygax SE, Schuyler JA, Kimmel LE, Trama JP, Mordechai E, Adelson ME. 2006. Erythromycin and Clindamycin Resistance in Group B Streptococcal Clinical Islolates. Antimicrob Agents Chemother 50(5):1875-1877.

Grant Funding

NIH 1RO1AI07394-01A2 (2008 – 2012). Candida glabrata Pdr1: Master Regulator of Azole Resistance. Co-PIs: Thomas D. Edlind (Drexel University College of Medicine) and Scott E. Gygax (Medical Diagnostic Laboratories, L.L.C) subcontract.

ABSTRACTS AND PRESENTATIONS

Balashov S, Konduru L, Mordechai E, Adelson ME, Gygax SE. 2011. A Survey of Neisseria gonorrhoeae  Mutations Conferring Resistance to Penicillin, Ciprofloxacin, Cefixime, Tetracycline, Azithromycin, and Spectinomycin. 51^th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL. Poster presentation.

Hilbert DW, Smith WL, Kaunitz AM, Mordechai E, Adelson ME, Trama JP, Gygax SE. 2011. Analysis of host antimicrobial protein production during bacterial vaginosis. 111^th American Society for Microbiology General Meeting, New Orleans, LA. Poster presentation.

Balashov S, Mordechai E, Gygax SE, Adelson ME. 2010. Development of a Diagnostic Test for Screening of Mutations in Neisseria gonorrhoeae Conferring Resistance to Penicillin, Ciprofloxacin, Cefixime, Tetracycline, Azithromycin, and Spectinomycin. Association for Molecular Pathology Conference, San Jose, CA. Poster presentation.

Chadwick SG, Overmyer CL, Mordechai E, Adelson ME, Gygax SE. 2010. Utilizing Single Nucleotide Polymorphisms in Staphylococcus aureus pbp3 for the Detection of Community Associated MRSA. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, MA. Poster presentation.

Vermitsky JP, Chadwick SG, Toner GJ, Mordechai E, Adelson ME, Gygax SE. 2010. CgUpc2 in the Master Regulator of Ergosterol Biosynthetic Genes in Candida glabrata. 11th Candida and Candidiasis Conference. Miami, Florida. Poster presentation.

Hilbert DW, Paulish TE, Mordechai E, Adelson ME, Trama JP. 2010. Escherichia coli alpha-hemolysin inhibits epithelial cytokine production. American Society for Microbiology 110th General Meeting, San Diego, CA. Poster presentation.

Edlind TD, Vermitsky JP, Gygax SE, Katiyar SK. 2010. Drug-target interaction mediates upregulation of multidrug transporter gene CDR1 in Candida glabrata. 11th Candida and Candidiasis Conference. Miami, Florida. Platform Presentation.

Knight SA, Vermitsky JP, Gygax SE, Edlind TD. 2010. Novel fluconazole resistance mechanism in Candida glabrata involving ERG upregulation. 11th Candida and Candidiasis Conference. Miami, Florida. Poster presentation.

Chadwick SG, Mordechai E, Adelson ME, Gygax SE. 2009. Susceptibility Profiles of Community-Associated MRSA Isolates from Cervicovaginal Swab Samples. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA. Poster presentation.

Edlind TD, Vermitsky JP, Gygax SE, Katiyar SK. 2009. Drug-Target Interaction Mediates Upregulation of Multidrug Transporter Gene CDR1 in Candida glabrata. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA. Platform Presentation.

Prasad A, Basu P, Mordechai E, Adelson ME, Gygax SE. 2009. PBP4 Polymorphisms Generate Penicillin Tolerance in Group B Streptococcus. 109th American Society for Microbiology General Meeting, Philadelphia, PA. Poster presentation.

Hilbert DW, Paulish TE, Mordechai E, Adelson ME, Trama JP. 2009. Uropathogenic Escherichia coli inhibits the activity of nuclear-localized NF-kB to obscure a Toll-like Receptor-independent Inflammatory stimulus. American Society for Microbiology 109th General Meeting. Philadelphia, PA. Poster presentation.

Vermitsky JP, Self MJ, Chadwick SG, Katiyar SK, Edlind TD, Gygax SE. 2009. cAMP-PKA kinase Tpk3 negatively regulates Candida glabrata Pdr1. 109th American Society for Microbiology General Meeting, Philadelphia, PA. Poster presentation.

Prasad A, Basu P, Mordechai E, Adelson ME, Gygax SE. 2008. Penicillin Tolerance in Group B. Streptococcus. 48th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington D.C. Poster presentation.

Vermitsky JP, Katiyar S, Gygax SE, Edlind TD. 2008. Multidrug resistance transcription factor Pdr1 is activated by MAP kinase Slt2 and repressed by protein kinase A Tpk3 in the opportunistic yeast Candida glabrata. 2008 Yeast Genetics and Molecular Biology Meeting, Toronto, Canada. Poster presentation.

Hilbert DW, Paulish TE, Libby EK, Pascal KE, Mordechai E, Adelson ME, Gygax SE, Trama JP. 2008. O Serotype, Virulence Factors, Plasmid Replicons, and Antibiotic Resistance of Rectal and Cervico-vaginal Escherichia coli Isolates. 108th American Society for Microbiology General Meeting, Boston, MA. Poster presentation.

Vermitsky JP, Self MJ, Katiyar S, Mordechai E, Adelson ME, Edlind TD, Gygax SE. 2008. The cAMP Protein Kinase A signal transduction pathway negatively regulates Pdr1, the master regulator of azole resistance in Candida glabrata. 10th Candida and Candidiasis Conference. Jersey City, New Jersey. Poster presentation.

Katiyar S, Vermitsky JP, Gygax SE, Edlind TD. 2008. Anatomy of Candida glabrata Pdr1, master regulator of azole resistance: evidence for activation by MAP kinase Slt2. 10th Candida and Candidiasis Conference. Jersey City, New Jersey. Poster presentation.

Edlind TD, Vermitsky JP, Pfaller M, Gygax SE, Katiyar S. 2008. Molecular mechanisms behind flucytosine resistance and azole-flucytosine antagonism in Candida glabrata. 10th Candida and Candidiasis Conference. Jersey City, New Jersey. Poster presentation.

Gygax SE, Prasad A, Trama JP, Mordechai E, Adelson ME. 2007. Penicillin tolerance in Group B Streptococcus. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL. Poster presentation.

Balashov SV, Mordechai E, Adelson ME. 2007. Development of a new high-throughput test for Cystic Fibrosis mutation screening. 13th Association for Molecular Pathology Annual Meeting. Los Angeles, California. Poster presentation.

Gygax SE, Schuyler JA, Trama JP, Adelson ME. 2007. A Novel ß-Hemolysin/Cytolysin Expression Phenotype in Group B Streptococcal Clinical Isolates. 107th American Society for Microbiology General Meeting, Toronto, Canada. Poster presentation.

Gygax SE, Prasad A, Schuyler JA, Trama JP, Mordechai E, Adelson ME. 2006. Penicillin tolerance in Group B Streptococcus. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA. Poster presentation.

Trama JP, Libby EK, Gygax SE, Mordechai E, Adelson ME. 2006. Differential induction of pro-inflammatory cytokines by vaginal and cervical epithelial cells in response to Group B Streptococci. The American Association of Immunologists. Boston, MA. Poster presentation.

Trama JP, Libby EK, Gygax SE, Mordechai E, Adelson ME. 2006. Host, pathogen, and drug interaction of an in vitro model of vaginal candidiasis. 9th Candida and Candidiasis Conference. Denver, CO. Poster presentation.

Gygax SE, Schuyler JA, Trama JP, Mordechai E, Adelson ME. 2005. Erythromycin and clindamycin resistance in Group B Streptococcus clinical islolates. 45th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC. Poster presentation.