FEMERISGenesisbiotech Group
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Research

At the core of any scientific progress is knowledge derived from research. FEMERIS supports translational research.

Biomarker Discovery and Diagnostic Test Development

We are applying strategies to discover and evaluate potential biomarkers for use in clinical laboratory testing. We are focused on biomarkers for early detection and evaluation of obstetric and gynecologic infectious diseases and medical conditions from sources such as vaginal, cervical, and uterine swabs, urine and blood.

Drug Target Discovery and High-Throughput Assay Development

We are interested in discovering novel and effective therapies of obstetric and gynecologic infectious diseases and medical conditions.

Probiotic Molecular Engineering

We are interested in developing yeast and bacterial probiotic strains to reduce the inflammation associated with Crohn’s and Irritable Bowel Diseases in the digestive tract. We are also interested in the development of these strains for the purpose of establishing maintaining a healthy vaginal flora for women with recurrent or chronic bacterial vaginosis.

Latest News

10/2015 - FEMERIS publication: Schuyler JA, Mordechai E, Adelson ME, Sobel JD, Gygax SE, Hilbert DW. Identification of intrinsically metronidazole-resistant clades of Gardnerella vaginalis. in Diagn Microbiol Infect Dis..

9/2015 - FEMERIS publication: Schuyler JA, Chadwick SG, Mordechai E, Adelson ME, Gygax SE, Hilbert DW. Draft Genome Sequence of a Metronidazole-Resistant Gardnerella vaginalis Isolate. in Genome Announc..

9/2015 - FEMERIS publication: Schuyler JA, Mordechai E, Adelson ME, Gygax SE, Hilbert DW. Draft Genome Sequence of a Metronidazole-Susceptible Atopobium vaginae Isolate. in Genome Announc..

7/2014 - Genesis Biotechnology Group (GBG) sponsored a two-day symposium on June 18th and 19th entitled “The Vaginal Microbiome and Bacterial Vaginosis.” Read Full Story

7/2014 - FEMERIS publication: Smith WL, Hedges S, Mordechai E, Adelson ME, Trama J, Gygax SE, Kaunitz AK, Hilbert DW. Cervical and vaginal flora is highly concordant with respect to bacterial vaginosis-associated organisms and commensal lactobacillus species in reproductive-aged women. J. Clin. Micrbiol. In Press.

7/2014 - FEMERIS publication: Whaley S, Caudle K, Vermitsky J-P, Chadwick SG, Toner G, Barker K, Gygax SE, Rogers PD. UPC2A is required for high-level azole antifungal resistance in Candida glabrata. Antimicrob. Agents Chemother. In Press.

10/2013 - FEMERIS Research Associate, Geoffrey Toner, and Director Dr. Scott Gygax had a manuscript entitled, “Novel antifungal drug discovery based on targeting pathways regulating the fungal-conserved Upc2 transcription factor” accepted into the journal Antimicrobial Agents and Chemotherapy.

9/2013 - FEMERIS Director Dr. Scott Gygax presented work done by Research Associate Sean Chadwick in a poster entitled “Disruption of Gardnerella vaginalis biofilms with clindamycin and metronidazole” at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy in Denver, Colorado.

8/2013 - FEMERIS Research Associate, Geoffrey Toner, and Director Dr. Scott Gygax had a manuscript entitled, “Flucytosine antagonism of azole activity versus Candida glabrata: role of transcription factor Pdr1 and multidrug transporter Cdr1” accepted into the journal Antimicrobial Agents and Chemotherapy.

5/2013 - FEMERIS Research Associates, Lamar Smith and Sean Chadwick, and Director Dr. Scott Gygax had a manuscript entitled, “Detection of epidemic USA300 community-associated MRSA strains using a single allele-specific PCR targeting a novel polymorphism of Staphylococcus aureus pbp3” accepted into the Journal of Clinical Microbiology.

1/2013 - FEMERIS Director Dr. Scott Gygax had a manuscript entitled, “Mixed vaginitis- more than coinfection and with therapeutic implications” accepted into the journal Current Infectious Disease Reports.

1/2013 - FEMERIS Research Associates, Jessica Schuyler and Sean Chadwick, and Director Dr. Scott Gygax had a manuscript entitled, “X-Plate Technology™: A new method for detecting fluconazole resistance in Candida species” accepted into the Journal of Medical Microbiology.